Research & Development

TECHNOLOGY PLATFORM

NanoDel's particles are designed for the targeting of drugs to the brain, retina or spinal cord. A drug is attached nanoparticles to polybutylcyanoacrylate-nanoparticles (PBCA) coated with a surfactant that carry the drug e.g. across the blood brain barrier (BBB). The nanoparticles range in diameter from 50 to 150 nm, and they are dispersed in an aqueous solution. Depending on the method of polymerization, drugs are either attached to the surface and/or are incorporated into polybutylcyanoacrylate-particles (PBCA). The nanoparticles can be stored either in lyophilized form or in solution. The technology is applicable to peptides, plasmids and small molecules.

This technology opens a new dimension for the treatment of diseases of the central nervous system (e.g. brain tumors, pain, migraine, etc.) and has been patented worldwide. This new carrier system can also be used for gene therapy, i.e. antisense-oligonucleotides crossing cell membranes. Drug- or gene-loaded nanoparticles can be transported into the cells of a specific organ where the polymeric nanoparticles are degraded and the drug is released. Drug-loaded nanoparticles are able to enhance the concentration of the drug inside the cells and at the same time protect the drug from being metabolized by the organism.

ASSEMBLING OF A DRUG-LOADED AND COATED NANOPARTICLE